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Development and commercialisation of a novel Livestock Schistosomiasis‐Point of Care‐Circulating Cathodic Antigen lateral flow test (LS‐POC‐CCA)
Investigator(s): Professor Joanne Webster
Amount Awarded: 94,839

Both humans and their domestic livestock across Africa carry a disproportionate burden of schistosomiasis due to socioeconomic and environmental conditions that favour the transmission of parasitic diseases. But many countries lack the finances and the point-of-care (POC) tools that are needed to [diagnose and ultimately] control the transmission of livestock schistosomiasis. Our original Bloomsbury SET- [in complement to prior BBSRC ZELS-] funding, which incorporated molecular, mathematical and epidemiological studies in association with social and ethnographic assessments, clearly identified the urgent need and the local, national and international demand, for non-invasive POC diagnostic tools and Test-Treat-Track (T3) implementation to control livestock schistosomiasis at both individual and herd levels. Furthermore, a POC-CCA currently available for human schistosomiasis, showed optimistic results in Senegalese livestock, with reasonable accuracy and superior to currently employed and available diagnostic tools for livestock schistosomiasis. However, our work also identified avenues for improvement and confounding factors that need to be identified and quantified. The novel livestock-specific POC CCA diagnostic tool [to be] developed [here] will provide decision-makers and veterinary health services at international, national and community levels with a critical tool that will enable targeted interventions that will both control schistosomiasis transmission and minimize the potential risk of emerging resistance to praziquantel, the only available treatment.