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Predicting treatment outcomes for neglected tropical diseases

Dr Martin Walker (RVC), Dr Jody Phelan (LSHTM) and Dr Julie Halder (RVC/IDDO) - £31,220
1 October 2019 to 31 March 2021 (Data Grant BSA34)

Analysis of approx 4,000 Individual Patient Data (IPDs) from 34 datasets on the IDDO platform using machine learning and/or statistical modelling techniques to address two key questions:

  1. Has the efficacy of the medicines used to treat schistosomiasis and soil-transmitted helminthiases (STHs) declined over the past decade of use or with the longevity of mass drug administration (MDA)?
  2. What alternative treatment regimens (doses and/or drug combinations) may be more efficacious for treating schistosomiasis and/or STHs?