Predicting treatment outcomes for neglected tropical diseases
Dr Martin Walker (RVC), Dr Jody Phelan (LSHTM) and Dr Julie Halder (RVC/IDDO) - £31,220
1 October 2019 to 31 March 2021 (Data Grant BSA34)
Analysis of approx 4,000 Individual Patient Data (IPDs) from 34 datasets on the IDDO platform using machine learning and/or statistical modelling techniques to address two key questions:
- Has the efficacy of the medicines used to treat schistosomiasis and soil-transmitted helminthiases (STHs) declined over the past decade of use or with the longevity of mass drug administration (MDA)?
- What alternative treatment regimens (doses and/or drug combinations) may be more efficacious for treating schistosomiasis and/or STHs?