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Development of a poultry vaccine platform based on transgenic coccidia parasites and evaluation of immunoprotection against necrotic enteritis

Dr Virginia Marugan-Hernandez (RVC), Dr Francisco Olmo (LSHTM), Prof Damer Blake (RVC), Prof Fiona Tomley (RVC) - £318,876
1 April 2019 to 31 March 2021 (Project Grant BSA21)
Poultry meat and egg production has significantly increased in the past two decades in response to increasing demand for food by the world’s population, especially in low-and-middle income countries. The sustainability of the poultry industry is challenged constantly by different factors. Increasing levels of antimicrobial resistance and public concerns about food safety, environment and animal welfare are driving changes in regulations which have operational consequences for the poultry sector. For example, control of important enteric diseases such as coccidiosis and necrotic enteritis (estimated annual costs of over US$5 billion) relies predominantly on the use of drugs. However, with new regulations to reduce usage of in-feed drugs and the preference of retailers to sell meat without antibiotics, the poultry industry needs to explore alternative approaches to avoid losses caused by re-emergence of these diseases. For many diseases, vaccination is the best alternative and research in this direction represents a positive way forward.

In this project, we propose to develop a flexible and novel vaccine platform for chickens based on the use of coccidian parasites as vectors. Using genetic engineering to produce parasites that express immunoprotective antigens from other avian pathogens, these novel vectors will be able to induce immunity against multiple infectious diseases using mass oral administration.In this project we will evaluate the efficacy of a vaccine product generated from this platform, aimed at controlling both necrotic enteritis and coccidiosis.

Research team:

Dr Virginia Marugan-Hernandez, Research Fellow in Vaccinology, RVC
Dr Francisco Olmo, Assistant Professor, Parasitology, LSHTM
Prof Damer Blake
, Professor of Parasite Genetics, RVC
Prof Fiona Tomley, Professor of Experimental Parasitology, RVC

 

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